Attorneys General from 41 states and territories are urging Congress to pass the Combating Illicit Xylazine Act, which would classify Xylazine as a federally controlled substance.
Xylazine is a tranquilizer intended to be used on large animals. Known by its street name “tranq,” it is not approved for any human use. The drug is not an opioid and therefore does not respond to the overdose reversal drug naloxone, thus greatly increasing its lethality when mixed with opioids and taken by humans.
In 2024, South Dakota Attorney General Marty Jackley proposed a bill making the use and possession of Xylazine outside of veterinary livestock purposes a crime. The bill was passed by the Legislature and signed into law by the Governor.
Attorneys General signed on to this letter are from:
New York, Arkansas, Connecticut, Tennessee, American Samoa, Arizona, California, Colorado, Delaware, District of Columbia, Georgia, Hawaii, Illinois, Indiana, Kansas, Kentucky, Louisiana, Maine, Michigan, Minnesota, Mississippi, Nevada, New Hampshire, New Jersey, New Mexico, North Carolina, North Dakota, Ohio, Oklahoma, Oregon, Pennsylvania, Rhode Island, South Carolina, U.S. Virgin Islands, Utah, Vermont, Virginia, Washington, West Virginia, and Wyoming.
A copy of the letter is found here: https://www.naag.org/wp-content/uploads/2026/03/Combating-Illicit-Xylazine_FINAL.pdf.






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